Proferrin® ES     Proferrin® Forte

There are two types of iron – ionic iron and heme iron polypeptide (HIP). Proferrin® is the only iron supplement made in the U.S. that uses no ionic, only Heme Iron Polypeptide derived from bovine sources. Proferrin® can help you maintain serum iron levels with fewer side effects.*

Choose the iron that works with your body!



Increased Absorption of Heme Iron*

Absorbing iron orally is difficult and Proferrin® helps solve this problem. A study performed at the University of Colorado compared taking 20 mg of elemental iron as heme iron polypeptide to taking 20 mg of ionic iron (ferrous fumarate) with a standard meal. The study demonstrated that HIP increased serum iron levels 23 times greater than ionic iron on a milligram-per-milligram basis. [1]

Proferrin® Contains Only Iron from Natural Sources*

The HIP in Proferrin® is extracted from hemoglobin, a naturally occurring iron source. [2] 

Proferrin® Doesn’t Compete with Other Nutrients*

The HIP found in Proferrin® is absorbed differently than traditional irons. Unlike other irons, Proferrin® does not compete with other nutrients. [3,4]

Proferrin® has Fewer Dietary Restrictions*

HIP does not appear to be affected by calcium, coffee, or other foods, and can be taken with meals. [1]

Proferrin® has Fewer Side Effects*

Traditional iron supplements are made with ionic irons, which can cause side effects such as constipation, cramping, gas and other forms of digestive system problems. [5,6,7] Proferrin® causes less gas [8] and is unlikely to cause common iron-related digestive system side effects. This is due to Proferrin’s Heme Iron Polypeptide being absorbed differently than that of non-heme iron.

If you take a traditional iron supplement to get your Recommend Daily Allowance (RDA), then you may be totally missing the target. The USDA recommendations assume that 75 percent of your daily iron comes from Heme Iron sources rather than non-heme iron.

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

1 Seligman, P. A., et. al., Nutrition Research, 2000. 20(9):1279-86.

2 Monsen, E. R., Journal of American Dietetic Association, 1988. 88(7):786-90.

3 Uzel, C., and Conrad, M. E., Seminars in Hematology, 1998. 35(1):27-34.

4 Lynch, S. R., Nutrition Reviews, 1997. 55(4):102-10.

5 Naude, S., et. al., The Journal of Clinical Pharmacology, 2000. 40:1447-51.

6 Gasche, C., et. al., Gut, 2004. 53:1190-97.

7 Gordeuk, V. R., et. al., Blood, 1986. 67(3):745-52.

8 Ghaddar, S., and Moore, G. M., Abstract presented at National Kidney Foundation, April 7, 2003. Dallas, TX.

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